Previously known as COMPLETE DAT

Key Advantages

  • IgE (Immunoglobulin E)
  • IgG4 (Immunoglobulin G – subtype 4)
  • Displays IgE in Relation to IgG4 (‘Blocking Potential’) for Each Food Group
  • Combined measurement of IgG & Complement to over 90 foods from a single blood serum sample
  • Assists confirmation of inflammatory response to IgG positive foods
  • The only test on the market that measures both IgG and immune complexes containing the complement fragment ‘C3d’ to multiple food antigens.
  • Includes a Candida Albicans Marker

Introduction

Combined testing of IgE, IgG4, IgG, & Complement allows one of the most thorough assessments of immune activity to specific foods assisting in forming the most appropriate dietary program for complex, multi-faceted and resistant immune/inflammation mediated pathology cases.

  • In addition to listing the individual IgE & IgG4 responses to each food, the report also groups the results into food groups, displaying their IgE and IgG4 readings in graphical form.
  • At very high levels, IgG4 antibodies alone can trigger an immune response within the body themselves.
  • However, data is available that provides support for the notion that IgG4 can serve another specific function of controlling IgE antigen recognition and consequently regulating anaphylactic reactions and IgE-mediated immunity.
  • IgG4 can act as a blocking agent by preventing IgE from binding to targeted receptor sites and releasing histamine. This is referred to as the blocking potential.


C3d (Complement component 3)

The Dietary Antigen Test (IgG with Complement) measures Complement activation for multiple foods. Complement activation is well-defined in the research as not only a cause of inflammation but one of the strongest causes.

C3d is an activator of the Complement cascade system. Reaction to the specified food will worsen if C3d activation is present along with an IgG antibody response.

When C3d is activated in response to an antigen, the C3 portion attaches to the antigen. This activation, even though it is independent, will amplify the reaction that occurs with total IgG greatly increasing inflammation and symptoms of sensitivity.

What is the C3d Pathway?

The Complement pathway acts as the body’s SWAT team to aggressively attack and clear threats, such as bacteria, viruses, protozoa, and allergens. It is part of the innate immune system, meaning that we are born with this immune defense mechanism.

Complement components patrol the blood harmlessly, but in an instant can go on the attack to kill and remove dangerous molecules from the body. When activated, the Complement pathway sets off a domino effect of inflammatory cytokines, mast cell degranulation (Histamine), and cell membrane destruction. It is a powerful protective force but can damage tissues if not kept under control.

Complement is a quantifiable, reliable biomarker of tissue inflammation.

What is the Relationship Between C3d Activation and IgG Reactivity?

It’s important to note that IgG is not the only factor in the reaction level for food sensitivities. To get a more complete look at the patient’s response and reaction level to that specific food, we often also need to measure the patient’s C3d reaction to that same food.

Complement serves as a link between the innate and adaptive immune response. This is because Complement uses immunoglobulins to help identify dangerous molecules that should be destroyed. IgG1, IgG3, and IgM antibodies can all activate Complement.


Why C3d Activation is so Important in Food Sensitivity Testing

  • When activated, the C3 component of the Complement system attaches to potential food antigens; these antigens may also induce a response from the acquired immune system.
  • Measurement of Complement can increase the inflammatory potential of a reaction to food by 1000 to 10,000 fold.
  • Complement helps differentiate which IgG titer is more inflammatory than others.
  • Complement is the link between the innate immune system and an acquired immune response, differentiating which white blood cell activations are truly inflammatory, limiting false positives.



IgG and Candida Connection

The report provided includes Candida albicans (a microscopic fungal organism and pathogenic yeast). High levels of IgG antibodies to Candida have been found in patients who reported many symptoms of yeast overgrowth. Candida problems are caused when the benign yeast form of Candida albicans mutates to its fungal form and produces a buildup of toxins in the body. Candida can overgrow areas of the intestinal mucosa resulting in numerous symptoms, including creating microscopic holes in the lining of the intestines, leading to what is commonly known as “leaky gut” syndrome. If Candida albicans proteins enter the blood, an inflammatory immune system response may be triggered.

A wide range of disorders have been linked to Candida overgrowth including autism, multiple sclerosis, depression, chronic fatigue, fibromyalgia, migraines, and irritable bowel syndrome. Immunocompromised patients with cancer or AIDS can have life-threatening complications if Candida enters the bloodstream, resulting in systemic candidiasis.

Use of antibiotics, oral contraceptives, chemotherapy, anti-inflammatory steroids, and diets high in sugar and starch increase susceptibility to Candida overgrowth. Research has revealed a relationship between health of the gastrointestinal tract and overall well-being. Imbalance between good and bad bacteria (dysbiosis) has been shown to worsen behaviour disorders, hyperactivity, aggression, and cause fatigue. Evidence is mounting that dysbiosis impairs the immune system and contributes to food allergies, digestive disorders, nutritional deficiencies, and cognitive dysfunction. Using the Dunwoody IgG+C3d test will help identify food intolerances and Candida sensitivity that may be creating a variety of problems for patients.

Practitioners may then recommend elimination of the identified foods and supplementation with various natural products that control Candida overgrowth and assist with healing of the gut. Depending on the levels of Candida and the severity of a patient’s symptoms, further testing may be recommended, including a Comprehensive Stool Analysis or Organic Acids Test.


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