Methylation: An Introduction


Methylation is a vital metabolic process that happens in every cell and every organ of the human body, taking place a million times a second. Life would simply not exist without it. Think of billions of little on/off switches inside your body that control everything from your stress response and how your body makes energy from food, to your brain chemistry and detoxification. That’s methylation.

Methylation is the transfer of a methyl group (1 Carbon atom & 3 Hydrogen atoms) onto amino acids, proteins, enzymes and DNA. The addition of a methyl group onto these molecules facilitates biochemical reactions vital to critical functions in our body such as: thinking, repairing DNA, turning on and off genes, fighting infections and detoxification (especially in the liver). It is also important for the proper functioning of the Hypothalamic-Pituitary-Adrenal (HPA) axis and critical for the synthesis of all neurotransmitters and histamine; for example, the enzyme that converts norepinephrine to epinephrine is dependent on methylation for activation.

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