Free podcast presented by Dr. Nirala Jacobi, Director for SIBOtest, in conversation with Dr. Carrie Jones, Medical Director of Precision Analytical (DUTCH testing).

From thesibodoctor.com

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Topics discussed include

  • Hormones and their relationship to functional digestive disorders.
  • Digestive flares before a woman’s period and why this can occur.
  • How gut inflammation can affect hormones – for example by raising cortisol, raising estrogen, raising 5 alpha reductase, lowering dehydroepiandrosterone sulfate (DHEA-S), affecting the absorption of nutrients that comprise hormones.
  • How lipopolysaccharides (LPS) and endotoxemia can impair and congest phase 1 and 2 liver detoxification pathways.
  • Nutritional cofactors required to support smooth Catechol-O-methyltransferase (COMT) functioning, especially in light of COMT single-nucleotide polymorphisms (SNPs).
  • Symptoms of estrogen dominance in men and women.
  • Hormone patterns related to a dysfunctional gut microbiome.
  • The estrobolome and how it can dictate how much beta-glucuronidase is produced, as well as how much dehydroepiandrosterone (DHEA) is released from the body.
  • All about estrogen metabolism, the different metabolites that are produced, which ones are beneficial, and the liver pathways used for processing.
  • Which estrogen metabolising pathways have associated cancer risk?
  • The role of beta-glucuronidase in disrupting estrogen excretion.
  • High toxic load patients and how hormone disruptors affect CYP enzymes and estrogen receptors.
  • How can a patient show symptoms of estrogen dominance and yet their hormonal profiles be ok?
    • Hint: If proliferative estrogen metabolising pathways favoured.
  • When to intervene for hormonal balance when client presents with gastrointestinal issues?
    • In light of high levels of beta-glucuronidase.
  • How to test for beta-glucuronidase – fecal.
  • What can we do about estrogen dominance?
    • Support for Phase 1
      • Diindolylmethane (DIM) for clients favouring unhealthy 4-OH E1 or 16a-OH E1 pathways.
      • Dietary adjustment to include Indole-3-carbinol (I3C) containing vegetables.
      • Broccoli sprout powder for sulforaphane (to activate quinone reductase)
        • Helps reverse the effects of going down unhealthy 4-OH E1 pathway.
      • Glutathione support with N-acetylcysteine (NAC), and liposomal glutathione.
    • Support for Phase 2 (COMT support)
      • Magnesium
      • Methylated B Vitamins
      • Methionine
      • Choline
      • S-Adenosyl-L-Methionine (SAMe)
    • Gut treatment
      • Calcium D-glucarate to help lower beta-glucuronidase levels.
      • Fibrous foods to bind free floating estrogen.
    • Note: Broccoli and fibrous products not recommended in phase 1 of SIBO treatment.
    • When to use binders in detoxification treatment.
    • Progesterone
      • Why can people with bloating potentially be progesterone deficient?
      • Progesterone cream in second half of the cycle versus vitex supplementation – what age groups are appropriate to each?
    • DUTCH testing – what is the difference between all the testing available?
    • Saliva tests – free hormones.
    • Blood tests – hormones are bound to sex hormone binding globulins or other carrier proteins.
    • DUTCH test – free hormones and metabolites.
    • Cortisol and cortisone – how to assess beyond an adrenal stress index, the difference between both forms, and why the body may have a pattern of inactivating cortisol into cortisone.
    • How to balance cortisol to cortisone ratio?
      • The role of licorice (Glycyrrhiza glabra)
    • Flatlining cortisol and its role as a marker for chronic infection, its association with an increased risk for cancer, and increased risk for autoimmune issues.
    • The cortisol awakening response and how it works with the thymus gland to destroy autoimmune antibodies.
    • The link between chronic infections and low cortisol, and how to address.
    • All about DHEA and DHEA-S
      • Counters stress
      • Energy, bone health, neurotransmitter balance, sex drive, muscle development.
      • 7-keto DHEA – what is this?
    • Supporting DHEA via adrenal support.
    • When and when not to test hormone levels.
    • Endometriosis and digestive disturbance due to adhesions, inflammation, and excess estrogen.
    • New developments in the hormonal testing field.
    • IBS symptoms around the period and why this may be.
      • The importance of structural alignment for uterine and intestinal health.
      • Therapy to address structural alignment – visceral manipulation, pelvic massages, and bodywork.
    • Flaxseeds
      • Helpful for estrogen dominance
      • Raises SHBG (note that flaxseeds preferentially bind testosterone – so care in women who are struggling with testosterone levels)
    • Soy
      • The role of fermented soy for hormonal balance in menopause.
      • Is soy estrogenic, or does it downregulate the proliferative estrogen pathway?
    • Dr Carrie Jones’ 2018 hormone education plans for practitioners and patients.