Free podcast presented by Dr. Nirala Jacobi, Director for SIBOtest, in conversation with Dr. Carrie Jones, Medical Director of Precision Analytical (DUTCH testing).
From thesibodoctor.com
Topics discussed include
- Hormones and their relationship to functional digestive disorders.
- Digestive flares before a woman’s period and why this can occur.
- How gut inflammation can affect hormones – for example by raising cortisol, raising estrogen, raising 5 alpha reductase, lowering dehydroepiandrosterone sulfate (DHEA-S), affecting the absorption of nutrients that comprise hormones.
- How lipopolysaccharides (LPS) and endotoxemia can impair and congest phase 1 and 2 liver detoxification pathways.
- Nutritional cofactors required to support smooth Catechol-O-methyltransferase (COMT) functioning, especially in light of COMT single-nucleotide polymorphisms (SNPs).
- Symptoms of estrogen dominance in men and women.
- Hormone patterns related to a dysfunctional gut microbiome.
- The estrobolome and how it can dictate how much beta-glucuronidase is produced, as well as how much dehydroepiandrosterone (DHEA) is released from the body.
- All about estrogen metabolism, the different metabolites that are produced, which ones are beneficial, and the liver pathways used for processing.
- Which estrogen metabolising pathways have associated cancer risk?
- The role of beta-glucuronidase in disrupting estrogen excretion.
- High toxic load patients and how hormone disruptors affect CYP enzymes and estrogen receptors.
- How can a patient show symptoms of estrogen dominance and yet their hormonal profiles be ok?
- Hint: If proliferative estrogen metabolising pathways favoured.
- When to intervene for hormonal balance when client presents with gastrointestinal issues?
- In light of high levels of beta-glucuronidase.
- How to test for beta-glucuronidase – fecal.
- What can we do about estrogen dominance?
- Support for Phase 1
- Diindolylmethane (DIM) for clients favouring unhealthy 4-OH E1 or 16a-OH E1 pathways.
- Dietary adjustment to include Indole-3-carbinol (I3C) containing vegetables.
- Broccoli sprout powder for sulforaphane (to activate quinone reductase)
- Helps reverse the effects of going down unhealthy 4-OH E1 pathway.
- Glutathione support with N-acetylcysteine (NAC), and liposomal glutathione.
- Support for Phase 2 (COMT support)
- Magnesium
- Methylated B Vitamins
- Methionine
- Choline
- S-Adenosyl-L-Methionine (SAMe)
- Gut treatment
- Calcium D-glucarate to help lower beta-glucuronidase levels.
- Fibrous foods to bind free floating estrogen.
- Note: Broccoli and fibrous products not recommended in phase 1 of SIBO treatment.
- When to use binders in detoxification treatment.
- Progesterone
- Why can people with bloating potentially be progesterone deficient?
- Progesterone cream in second half of the cycle versus vitex supplementation – what age groups are appropriate to each?
- DUTCH testing – what is the difference between all the testing available?
- Saliva tests – free hormones.
- Blood tests – hormones are bound to sex hormone binding globulins or other carrier proteins.
- DUTCH test – free hormones and metabolites.
- Cortisol and cortisone – how to assess beyond an adrenal stress index, the difference between both forms, and why the body may have a pattern of inactivating cortisol into cortisone.
- How to balance cortisol to cortisone ratio?
- The role of licorice (Glycyrrhiza glabra)
- Flatlining cortisol and its role as a marker for chronic infection, its association with an increased risk for cancer, and increased risk for autoimmune issues.
- The cortisol awakening response and how it works with the thymus gland to destroy autoimmune antibodies.
- The link between chronic infections and low cortisol, and how to address.
- All about DHEA and DHEA-S
- Counters stress
- Energy, bone health, neurotransmitter balance, sex drive, muscle development.
- 7-keto DHEA – what is this?
- Supporting DHEA via adrenal support.
- When and when not to test hormone levels.
- Endometriosis and digestive disturbance due to adhesions, inflammation, and excess estrogen.
- New developments in the hormonal testing field.
- IBS symptoms around the period and why this may be.
- The importance of structural alignment for uterine and intestinal health.
- Therapy to address structural alignment – visceral manipulation, pelvic massages, and bodywork.
- Flaxseeds
- Helpful for estrogen dominance
- Raises SHBG (note that flaxseeds preferentially bind testosterone – so care in women who are struggling with testosterone levels)
- Soy
- The role of fermented soy for hormonal balance in menopause.
- Is soy estrogenic, or does it downregulate the proliferative estrogen pathway?
- Dr Carrie Jones’ 2018 hormone education plans for practitioners and patients.
- Support for Phase 1