Suggested Use: Adults hold 1-2 tablets under tongue until dissolved, one to three times per day, or as prescribed by a healthcare practitioner.
| Sublinqual Hydroxy B12 120 tablets AUST-L: 448831 |
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| Each tablets Contains: | |
| Hydroxocobalamin | 1,000 micrograms |
| Excipients: Xylitol, Hypromellose,
Ascorbyl Palmitate,
Colloidal Anhydrous Silica Suitable for vegans. |
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In a prospective open-labelled study seeking to determine if oral sublingual B12 administration can provide an alternative to intramuscular injection, 18 patients with cobalamin deficiency of various causes were treated with 1,000mcg sublingual cobalamin preparation for 2-4 weeks.
After washout, a significant increase in serum cobalamin concentration (as much as four-fold compared with the pretreatment concentration) was seen in most patients, with a mean change of more than double pretreatment levels. No patient experienced side effects.
The authors concluded that sublingual cobalamin is an effective, safe, and convenient treatment, which provides rapid restoration of serum cobalamin concentrations and should be considered as an alternative method of administration.
In a follow up case study, Chalmers, Bain & Costello concluded that “Oral Hydroxocobalamin therapy has an important place in the maintenance therapy of patients with cobalamin deficiency syndromes and with cobalamin cofactor synthesis disorders, it is preferred to intramuscular injections by patients, and deserves to receive wider publicity and use”.
Lederle FA, 1991, ‘Oral cobalamin for pernicious anaemia: medicine’s best kept secret?’, JAMA, vol. 265, pp. 94-5.
Elia M 1998, ‘Oral or parenteral therapy for B12 deficiency’, Lancet, vol. 352, pp. 1721-2.
Delpre G, Stark P & Niv Y, 1999, ‘Sublingual therapy for cobalamin deficiency as an alternative to oral and parenteral cobalamin supplementation’, Lancet, vol. 354(9180), pp. 740-1.
Chalmers, RA, Bain, MD & Costello, I 1999 Paediatric Metabolism Unit, Department of Child Health, St George’s Hospital Medical School, London SW17 ORE, UK.
Iodine is utilised by thyroid cells to form Thyroxine (T4) and small amounts of Triiodothyronine (T3). Deficiency of iodine and potentially L-Tyrosine can reduce the amount of inactive T4 able be converted into active T3.
Selenium, as selenoproteins (along with zinc), is key for conversion of T4 to T3. One double-blind placebo-controlled trial by Olivieri et al, found significant improvement in selenium indices (following selenium supplementation) including a decrease in T4, while the placebo group had unchanged serum selenium, erythrocyte glutathione peroxidase activity and thyroid hormones. Therefore, authors concluded that selenium status influences thyroid hormones.
Kobayashi et al found selenium supplementation in patients with abnormal thyroid levels resulted in a significantly decreased TSH, improved T4/free T3 ratio and increased free T3.
Vitamin B12 deficiency is common in hypothyroid patients along with iron and haemoglobin, with some studies citing rates as high as 40% of study participants.
Vitamin K2 is necessary for the activation of the thyroid supportive nutrients Vitamins D and A and may assist in calcium regulation, which is altered in hypothyroidism.
Liu and colleagues examined the relationship between thyroid hormone levels (free triiodothyronine [T3], free thyroxine [T4], total T3, total T4 and thyroid stimulating hormone [TSH], and anthropometric measurements and biochemical parameters.
Assessed at baseline, 6 months, and 24 months, were 569 overweight and obese participants, aged 30-70 years with normal thyroid function.
Higher levels of free T3 and free T4 were significantly associated with greater weight loss at 6 months and 24 months alongside weight loss diets (TSH levels did not predict weight loss).
High doses of vitamin B12 have not commonly been associated with side effects. However, doses of Xylitol higher than the recommended dose range may result in bloating or diarrhoea in some individuals.
Sublingual Hydroxy-B12 is a pure and hypoallergenic product, developed to meet the needs of even the most sensitive patients. Formulated with no harsh or irritating excipients, ensures comfort, safety and efficacy for improved patient compliance and results.
This product does NOT contain wheat, gluten, dairy, lactose, egg, yeast, soy, artificial colours, artificial sweeteners, or artificial flavours. This product also does not contain synthetic preservatives, stearate lubricants and other commonly detrimental excipients.
Hydroxycobalamin is a naturally occurring form of vitamin B12, preferred in many countries due to its long retention of activity in the body and superior availability to cells over Cyanocobalamin.
Hydroxocobalamin is a scavenger of cyanide and nitric oxide, and can be converted to methylcobalamin in the body as needed.
Hydroxycoblamin is relatively stable compared to Methylcobalalmin (which readily oxidises back to Hydroxycobalamin – after losing its methyl group in the mouth).
The potential for supplemental methyl B12 to dissociate to hydroxy B12 in the mouth is commonly understood pharmacologically (rather than being extensively studied in any clinical trials). Leading Hydroxy B12 to perhaps be considered the more stable option.
Conversely, Hydroxyl B12 can readily be converted to methylcobalamin or adenosylcobalamin as needed in the body (which may be beneficial as both forms are required by the body).
Whenever there is either little effect, poor resolution of B12 deficiency, or even a worsening of symptoms after taking Methylcobalamin, Hydroxycobalamin can be a better tolerated form of vitamin B12 in many individuals.
Especially those with certain genetic polymorphisms (SNPs) that may benefit from receiving ample physiologically usable vitamin B12, without overriding the body’s natural methyl production feedback mechanisms.
RN Labs deliver premium-grade, strictly clinician-only supplements, formulated for everyone, even your most sensitive patients. All our product labels provide full-label transparency – listing all excipients – so you can be confident that you are giving your patient a pure, high-quality product that you and your patient can rely on.
RN Labs products define the highest level of purity, quality and innovation.
We have always voluntarily provided full label transparency –
meaning everything in the bottle is listed on the label.
Like you, nothing is dearer to us than our health and helping others achieve optimum wellness. It’s why we are so fastidious about developing products that even the most sensitive individuals can take – free from harsh excipients and inappropriate compound
forms.
We are committed to improving client outcomes.
We always choose the most scientifically validated forms of nutrients available and formulate products based on clinical
research.
Our product formulations are only produced if we can source ingredients that meet our high
standards of purity through third- party testing. We only ever use manufacturers that do not take short-cuts to facilitate easier or cheaper manufacturing.
Jess is a qualified Nutritionist with a Bachelor of Health Science in Nutritional Medicine. She believes that there is no one size fits all approach and is passionate about educating, inspiring and supporting clients and practitioners with a customised approach to healthcare. Specialties include preconception, pregnancy, post-natal and infant care.
Jess is excited to build relationships, educate and share her knowledge with both retail and practitioners in South Queensland and Northern NSW.
Lauren is an NHAA accredited Clinical Naturopath with a Bachelor of Health Science. She is incredibly passionate about natural health and educating clients on the foundational importance of nutrition, lifestyle and stress management and believes complimenting these building blocks with nutraceutical support and functional testing often holds the key to optimal health and vitality. Lauren looks forward to supporting practitioners and clients in these key areas.
Specialties include supporting thyroid health, digestive disorders and mental health.
