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Detailed Test Information
The TOXDetect is a urine test that can be used for assessing toxic chemical exposure through products like pharmaceuticals, pesticides, packaged foods, household products, and environmental pollution.
Mosaic Diagnostics (formerly Great Plains) has created TOXDetect, a toxic non-metal chemical profile that screens for the presence of 19 different toxic chemicals including organophosphate pesticides, phthalates, benzene, xylene, vinyl chloride, pyrethroid insecticides, acrylamide, perchlorate, diphenyl phosphate, ethylene oxide, acrylonitrile, and more.
Phthalates
Enhanced insight into phthalate exposure is provided by measuring five phthalate metabolites. Phthalates are a family of widely used chemicals found in most products that have contact with plastics during production, packaging, or delivery. These plasticizers which make plastic more flexible, and durable are associated with a number of health problems including reproductive, neurological, respiratory, and increased risk of certain types of cancer. Most significantly they are known as endocrine disruptors. Phthalates are referred to as “the everywhere chemical” due to the fact they are used in hundreds of products, including toys, food packaging, shampoo, vinyl flooring, and more. Detection of Monoethylphthalate (MEP),Monobutyl phthalate (MBP), Mono-2ethylhexyl phthalate (MEHP), Mono-(2-ethyl-5-oxohexyl) phthalate (MEOHP) and Monoisobutyl phthalate (MiBP) in urine is an indicator of exposure.
Xylene
Xylene is widely used in industry and medical laboratories. Xylene is released primarily from industrial sources. One can also come in contact with xylene through automobile exhaust and a variety of consumer products such as cigarette smoke, paints, varnish, rust preventives, and shellac. Literature suggests that xylene exposure causes toxic effects on various systems of the body. Longer term effects can damage the liver and kidneys. Detection of 2-3-4 Methylhippuric Acid (2,-3-,4-MHA) in urine is an indicator of exposure.
Styrene/Ethylbenzene
Styrene is widely used to make plastics and rubber, which are used to manufacture a variety of products, such as insulation, pipes, automobile parts, printing cartridges, food containers, and carpet backing. Exposure may occur through ingestion via transfer to foods, especially fatty foods heated in styrene containers, through breathing indoor air that has styrene vapors from building materials, photocopiers, tobacco smoke, and other products. Styrene and styrene oxide have been implicated as reproductive toxicants, neurotoxicants, and linked to an increased risk of leukemia and lymphoma. Detection of Phenylglyoxylic Acid (PGO) in urine is an indicator of exposure.
Benzene
Benzene has been used extensively in the past as an industrial solvent; however, due to its toxicity and potential health hazards, its use has been reduced. Exposure can occur occupationally, in the general environment and in the home as a result of the ubiquitous use of benzene-containing petroleum products, including motor fuels and solvents. Benzene exposure has been linked to respiratory, hepatic, cardiovascular, immune, nervous, and endocrine system dysfunction. Detection of N-Acetyl Phenyl Cysteine (NAP) in urine is an indicator of exposure.
Acrylonitrile
Acrylonitrile exposure occurs through the use of products containing acrylonitrile, such as acrylic fiber clothing or carpeting, acrylonitrile-based plastics, leaching into foods from plastic food containers, and cigarette smoke. Humans exposed to high levels via inhalation experienced respiratory tract irritation, labored breathing, dizziness, cyanosis, limb weakness and convulsions. It is considered a probable human carcinogen, with evidence suggesting an association with lung cancer. Detection of N-Acetyl (2-Cyanoethyl) Cysteine (NACE) in urine is an indicator of exposure.
1-bromopropane
1-bromopropane is an organic solvent used for metal cleaning, foam gluing, and dry cleaning. Studies have shown that 1-BP is a neurotoxin as well as a reproductive toxin. Research indicates that exposure to 1-BP can cause sensory and motor deficits. Chronic exposure can lead to decreased cognitive function and impairment of the central nervous system. Acute exposure can lead to headaches. Detection of N-Acetyl (Propyl) Cysteine
(NAPR) in urine is an indicator of exposure.
1,3 butadiene
1,3 butadiene is a petrochemical used to produce synthetic rubber used for car and truck tires and is also an environmental toxicant found in car exhaust, combustion of fuels for warmth or energy production and cigarette smoke. It is associated with adverse health impacts, including cancer, and cardiovascular disease. The International Agency for Research on Cancer (IARC) concluded that 1,3 butadiene is a human carcinogen. Detection of N-Acetyl (3,4-Dihydroxybutyl) Cysteine (NADB) in urine is an indicator of exposure.
Ethylene Oxide, Vinyl Chloride
Ethylene oxide is a man made substance widely used in the production of various chemicals such as plastics, textiles and antifreeze (ethylene glycol). Additionally, ethylene oxide is commonly used as a sterilizing agent for medical equipment. Inhalation is the most common route of exposure in occupational settings and via tobacco smoke. There is some evidence that exposure to ethylene oxide can cause a pregnant woman to lose a pregnancy. The International Agency for Research on Cancer (IARC) concluded that ethylene oxide is a known human carcinogen, exposure is linked to increased risk of leukemia and non-Hodgkin’s lymphoma. Vinyl chloride is colorless gas used primarily to manufacture polyvinyl chloride (PVC) and widely used in numerous products such as pipes, wire and cable insulation, packaging materials, various construction materials and disposable medical products. Inhalation is the most common route of exposure primarily in occupational settings, also via smoke from cigars or cigarettes. Acute high-level exposure can produce headaches, dizziness, drowsiness, and loss of consciousness. Long term exposure can result in hepatocellular changes and increased incidence of liver cancer. The International Agency for Research on Cancer (IARC) concluded that vinyl chloride is carcinogenic to humans. Detection of 2-Hydroxyethyl Mercapturic Acid (HEMA) in urine is an indicator of exposure.
2,4-Dichlorophenoxyacetic Acid
2,4-Dichlorophenoxyacetic Acid (2,4-D) is one of the most widely used herbicides in the world. It is commonly used in agriculture and landscaping. Chronic exposure to lower levels of 2,4-D has been associated with potential health effects, including endocrine disruption, reproductive effects, developmental effects, and increased risk of non-Hodgkin lymphoma. Detection of 2,4-Dichlorophenoxyacetic Acid (2,4-D) in urine is an indicator of exposure.
Pyrethroids
Pyrethroids are widely used in agriculture, household insect control, and veterinary medicine. Pyrethroids work by targeting the nervous system of insects, causing hyperexcitation and paralysis. The most common potential impacts to health include neurobehavioral, neurodevelopmental, and endocrine disruption. Exposure has also been associated with an increased risk of all-cause and cardiovascular disease mortality. Detection of 3-Phenoxybenzoic Acid (3-PBA) in urine is an indicator of exposure.
Organophosphates
Organophosphate pesticides are widely used in agriculture to control pests, as well as in residential settings to manage insects and rodents. The organophosphate pesticides work by inhibiting the activity of acetylcholinesterase, an enzyme essential for proper nerve function. Exposure to organophosphates has been associated with neurological deficits, neurodegenerative diseases, peripheral nerve effects, and neurodevelopmental issues. Additionally, long-term exposure has been linked to oxidative stress, psychological effects, and liver function abnormalities. Detection of Diethylphosphate (DEP) in urine is an indicator of exposure.
Triphenyl Phosphate
Triphenyl phosphate is commonly used as a flame retardant in consumer products such as furniture, electronics, and textiles. It is also present in personal care products, such as nail polish and cosmetics, and contact with these products can lead to dermal absorption. Triphenyl phosphate can also be ingested from food and beverages due to migration from packaging materials or contamination during food processing. Exposure to triphenyl phosphate can alter endocrine function and impact reproduction. Altered thyroid function and decreased semen quality has been observed in humans. Detection of Diphenyl Phosphate (DPP) in urine is an indicator of exposure.
Acrylamide
Acrylamide is formed when starchy foods, such as potatoes, grains, and coffee beans, are cooked at high temperatures. Other potential sources of acrylamide exposure include cigarette smoke, as acrylamide is formed during the combustion of tobacco, and certain cosmetic products that may contain acrylamide as a contaminant. Acrylamide has been linked to an increased risk of cancer, particularly in organs such as the kidneys, ovaries, and uterus. Other potential health effects include neurotoxicity, genotoxicity, reproductive toxicity, hepatotoxicity, immunotoxicity, and increased cardiovascular risk. Detection of N-Acetyl (Carbomethyl) Cysteine (NAE) in urine is an indicator of exposure.
Perchlorate
Perchlorate is a chemical used in fireworks, road flares, explosives, and rocket fuel. Perchlorates are considered environmental contaminants due to their widespread use and persistence in the environment. Perchlorate can also enter the food supply through contaminated water used for irrigation or through food processing. Milk is also a source of perchlorate, the content in milk is related to the presence of perchlorate in feed. Perchlorate inhibits the thyroid’s uptake of iodine. This interference can disrupt thyroid function and lead to health problems such as hypothyroidism (underactive thyroid) or other thyroid disorders. Pregnant women, infants, and children are particularly vulnerable to the effects of perchlorate exposure on thyroid function. Detection of Perchlorate (PERC) in urine is an indicator of exposure.
Bisphenol S
Bisphenol A (BPA) is a chemical produced in the manufacturing process of polycarbonate plastics and epoxy resins and is found in many consumer products such as food and beverage containers, medical devices, shatterproof windows, toys, dental sealants, some metal food container liners, water supply pipes, and more, which makes exposure quite common. BPA is most often leached into food from food and beverage containers and then ingested.
Atrazine Mercapturate
Atrazine Mercapturate Is a urinary metabolite of atrazine, a widely used triazine herbicide. Atrazine inhibits photosynthesis in plants and is used to kill broadleaf weeds, especially in agriculture for crops such as corn and along roadways.
Glyphosate
Glyphosate is the world’s most widely produced herbicide. It is a broad-spectrum herbicide that is used in more than 750 different products for agriculture and forestry to home use.
Parabens
Parabens are a class of synthetic chemicals commonly used as preservatives in cosmetics, personal care products, pharmaceuticals, and some food items. Some individuals may experience skin irritation or allergic reactions to parabens. Concerns about their impact on human health include the potential for endocrine disruption, links to breast cancer, and increased BMI.
Analytes in this category include Butylparaben (BuP), Ethylparaben (EtP), Methylparaben (MeP) and Propylparaben (PrP).
Oxybenzone
Oxybenzone is a chemical compound of the benzophenone class often used in sunscreen and other personal care products due to its ability to absorb ultraviolet light protecting the skin from UV radiation making exposure common.2 Oxybenzone is often found in effluents of wastewater treatment plants and surface waters.
If you or a patient has had a TOXDetect profile and/or a Glyphosate test run and found moderate-high levels of any compounds, there are things you can do to help your body eliminate the toxins and to prevent future exposures. The first steps to reducing the amount of toxins presently in the body are to switch to eating only organic food and drinking water that has common toxins, including pesticides filtered out. Most conventional food crops are exposed to larger and larger doses of pesticides and herbicides, and by switching to organic you will prevent exposure to hundreds of these toxicants. Many of these chemicals have also contaminated our water supplies. Installing a high-quality water filtration system in the home that eliminates them is important to do and there are several options available.
The next step to avoiding future exposures is to change the products you use on a daily basis – from food and beverage containers to beauty and cleaning products. Instead of using plastic water bottles and food containers, switch to glass or metal. Never microwave food in plastic or styrofoam containers and do not drink hot beverages from plastic or styrofoam cups. Make sure your shampoo, soaps, lotions, and other beauty products are free of phthalates. Use cleaning products made from natural ingredients or make your own at home.
To eliminate toxins from the body, we highly recommend exercise and the use of saunas, especially infrared sauna therapy to rid many chemicals through sweat. Infrared sauna is superior to conventional sauna because it reaches deeper into the body, increasing the circulation in the blood vessels, and causing the body to start to releasing many of the chemicals stored in body fat.
There are two supplements that are particularly useful in helping the body detoxify. The first is glutathione, or its precursor N-acetyl cysteine. Glutathione is one of the most common molecules used by the body to eliminate toxic chemicals. If you are constantly exposed to toxicants your stores of glutathione could be depleted. The second supplement is vitamin B3 (niacin). Some may not enjoy the flushing that can happen when taking niacin, however, this flushing is from the blood vessels dilating, which is useful in the detoxification process. If sensitive to the flushing, start with the lowest recommended dose and work up from there.
$529.00
For up-to-date prices on all tests and to authorise, please see the Practitioner Hub.
| GPL Tox | TOXDetect |
| 2-Hydroxyisobutyric Acid (2HIB) | Monoethylphthalate (MEP) |
| Monoethylphthalate (MEP) | Monobutyl phthalate (MBP) |
| 2-3-4 Methylhippuric Acid (2,-3-,4-MHA) | Mono-2ethylhexyl phthalate (MEHP) |
| Phenylglyoxylic Acid (PGO) | Mono-(2-ethyl-5-oxohexyl) phthalate (MEOHP) |
| N-acetyl phenyl cysteine (NAP) | Monoisobytyl phthalate (MiBP) |
| N-acetyl(2-cyanoethyl)cysteine (NACE) | 6 – 2-3-4 Methylhippric Acid (2,-3-,4-MHA) |
| Perchlorate (PERC) | Phenylglyoxylic Acid (PGO) |
| Diphenyl phosphate (DPP) | N-Acetyl Phenyl Cysteine (NAP) |
| 2-hydroxyethyl mercapturic (HEMA) | N-Acetyl (2-Cyanoethyl) Cysteine (NACE) |
| N-acetyl(propyl)cysteine (NAPR) | N-Acetyl (Propyl) Cysteine (NAPR) |
| N-acetyl(2-hydroxypropyl)cysteine (NAHP) | N-Acetyl (3,4-Dihydroxybutyl) Cysteine (NADB) |
| N-acetyl-S-(2-carbamoylethyl)cysteine (NAE) | Hydroxyethyl Mercapturic Acid (HEMA) |
| N-acetyl(3,4-dihydroxybutyl)cysteine (NADB) | 2,4-Dichlorophenoxyacetic Acid (2,4-D) |
| Dimethylphosphate (DMP) | 3-Phenocybenzoic Acid (3-PBA) |
| Diethylphosphate (DEP) | Diethylphosphate (DEP) |
| 2,4-Dichlorophenoxyacetic Acid (2-,4-D) | Diphenyl Phosphate (DPP) |
| 3-Phenoxybenzoic Acid (3PBA) | N-Acetyl (Carbomethyl) Cystiene (NAE) |
| Tiglylglycine (TG) | Perchlorate (PERC) |
| Bisphenol S (BPS) |
Mosaic Diagnostics (formerly Great Plains) is a research-based clinical laboratory and world leader in providing testing for metabolic, genetic, mitochondrial, and environmental factors in chronic illnesses.
They are dedicated to assisting healthcare practitioners help patients achieve their maximum potential through quality laboratory testing. Mosaic Diagnostics provide reliable, comprehensive, and understandable scientific results, using the latest technology and proven techniques.
Jess is a qualified Nutritionist with a Bachelor of Health Science in Nutritional Medicine. She believes that there is no one size fits all approach and is passionate about educating, inspiring and supporting clients and practitioners with a customised approach to healthcare. Specialties include preconception, pregnancy, post-natal and infant care.
Jess is excited to build relationships, educate and share her knowledge with both retail and practitioners in South Queensland and Northern NSW.
Lauren is an NHAA accredited Clinical Naturopath with a Bachelor of Health Science. She is incredibly passionate about natural health and educating clients on the foundational importance of nutrition, lifestyle and stress management and believes complimenting these building blocks with nutraceutical support and functional testing often holds the key to optimal health and vitality. Lauren looks forward to supporting practitioners and clients in these key areas.
Specialties include supporting thyroid health, digestive disorders and mental health.
