Berbersorb Feature
Berbersorb Feature
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Suggested Use: Adults take 1-4 capsules, once or twice per day with food depending on clinical goals and responses, and according to practitioner judgement.
| Berbersorb 60 capsules | |
| Each Vegetarian Capsule Contains: | |
| Berbevis® Berberine Phytosome® | 250 mg |
| containing Berbers aristata root dry ext. concentrate | 105 mg |
| equivalent to dry Berbers aristata root | 5.52 mg |
| standardised to contain Berberine | 75 mg | Excipients: Pea powder, Lecithin (Sunflower), Hypromellose
(Capsule), Vitis vinifera (Grape) seed extract, Leucine,
Microcrystalline Cellulose, Hyprolose, Colloidal Anhydrous Silica. Suitable for vegans. |
Phytosome® form (Phytophospholipid complex) allows for the absorption and sustained release of quantities of Berberine hydrochloride required for effective metabolic support.
A study by Petrangolini et al. (2021) found that the solubility of Berberine Phytosome® form demonstrated an increase of solubility in simulated gastric and intestinal fluids and an improved bio accessibility at intestinal level along with a lower cytotoxicity.
The pharmacokinetic profile of the oral administration to healthy volunteers confirmed that Berberine Phytosome significantly ameliorated berberine absorption, in comparison to conventional berberine extracts, without any of the commonly observed side effects, such as gastrointestinal irritation.
The Berberine plasma concentrations (area under the curve) observed with both doses of Phytosome® form of Berberine were higher than those of standard Berberine supplement administration. Furthermore, Berberine Phytosome® improved Berberine bioavailability significantly, around 10 times on molar basis and with observed dose linearity.
Clinical trials assessing Berberine, combined with Metformin have demonstrated significantly decreased HbA1c levels with less adverse effects, compared with Metformin alone.
The combination of Metformin and Berberine exerted synergistic lipid-lowering effects on HepG2 cells by reducing total lipid content, triglyceride level, and the expression of the genes involved in lipogenesis.
Berberine may play a role in PCOS management and treatment strategies. One study found after 60 days of supplementation with a phytosomal® Berberine formulation in PCOS females, there was a statistically significant decrease in insulin resistance, CRP, TNF-alpha?, Triglycerides, Testosterone, Body Mass Index (BMI), Visceral Adipose Tissue (VAT), fat mass, GAGS and CADI scores, and a statistically significant increase in sex hormone-binding globulin (SHBG).
Another study by An et al. (2014) evaluated the clinical, metabolic and endocrine effects of Berberine versus Metformin in PCOS women scheduled for IVF treatment. Compared with placebo, greater reductions in total Testosterone, free androgen index, fasting glucose, fasting insulin and HOMA-IR, and increases in SHBG, were observed in the Berberine and Metformin groups. Three months of treatment with Berberine or Metformin before the IVF cycle increased the pregnancy rate and reduced the incidence of severe ovarian hyperstimulation syndrome. Furthermore, treatment with Berberine, in comparison with Metformin, was associated with decreases in BMI, lipid parameters and total FSH requirement, and an increase in live birth rate, with fewer gastrointestinal adverse events. Berberine and Metformin treatments prior to IVF improved the pregnancy outcome by normalising the clinical, endocrine and metabolic parameters in PCOS women. The authors stated that “Berberine has a more pronounced therapeutic effect and achieved more live births with fewer side effects than Metformin.”
At a cellular level, the inhibitory effect of Berberine on mitochondrial enzymes is probably responsible for many of its biological activities, including the activation of low-density lipoprotein receptor (LDLR), AMP-activated protein kinase (AMPK) and insulin receptor (InsR); these biological activities contribute to ameliorate peripheral blood metabolic profiles, e.g. by reducing plasma lipids and glucose levels, thus improving signs and symptoms of metabolic disorders.
Berberine is recognised as a naturally derived bioactive alkaloid obtained from the berberis genus plants, proven to favourably modulate blood profiles such as plasma lipids and glucose levels, therefore contributing to metabolic wellbeing.
Finding a way to maintain metabolic balance is a key global health challenge, among the growing incidence of chronic metabolic health conditions such as Metabolic Syndrome, PCOS or Type-II Diabetes.
Using a patented phytosome technology, the absorption of berberine is optimised 10 times – utilising this form has shown in clinical trials to contribute to metabolic wellbeing by lowering blood glucose, and to have a positive effect on body composition, inducing redistribution of adipose tissue even without subjects being on a low-calorie diet.
RN Labs deliver premium-grade, strictly clinician-only supplements, formulated for everyone, even your most sensitive patients. All our product labels provide full-label transparency – listing all excipients – so you can be confident that you are giving your patient a pure, high-quality product that you and your patient can rely on.
RN Labs products define the highest level of purity, quality and innovation.
We have always voluntarily provided full label transparency –
meaning everything in the bottle is listed on the label.
Like you, nothing is dearer to us than our health and helping others achieve optimum wellness. It’s why we are so fastidious about developing products that even the most sensitive individuals can take – free from harsh excipients and inappropriate compound
forms.
We are committed to improving client outcomes.
We always choose the most scientifically validated forms of nutrients available and formulate products based on clinical
research.
Our product formulations are only produced if we can source ingredients that meet our high
standards of purity through third- party testing. We only ever use manufacturers that do not take short-cuts to facilitate easier or cheaper manufacturing.
We work with healthcare clinicians to bring their patient’s personalised care that’s unique to them.
We believe that every one of us is an individual when it comes to our health.
RN Labs Pty Ltd
18/93 Rivergate Place,
Murarrie, QLD 4172
Jess is a qualified Nutritionist with a Bachelor of Health Science in Nutritional Medicine. She believes that there is no one size fits all approach and is passionate about educating, inspiring and supporting clients and practitioners with a customised approach to healthcare. Specialties include preconception, pregnancy, post-natal and infant care.
Jess is excited to build relationships, educate and share her knowledge with both retail and practitioners in South Queensland and Northern NSW.
Lauren is an NHAA accredited Clinical Naturopath with a Bachelor of Health Science. She is incredibly passionate about natural health and educating clients on the foundational importance of nutrition, lifestyle and stress management and believes complimenting these building blocks with nutraceutical support and functional testing often holds the key to optimal health and vitality. Lauren looks forward to supporting practitioners and clients in these key areas.
Specialties include supporting thyroid health, digestive disorders and mental health.
