Case Study: Focus on Citrulline


• L-Citrulline is the natural precursor of L-Arginine and the substrate for nitric oxide synthase (NOS) in the production of NO. This has been shown to be effective in improving NO production and cardiovascular function in cardiovascular diseases which are associated with endothelial dysfunction, such as hypertension, heart failure, atherosclerosis, diabetic vascular disease and ischemia reperfusion injury.

• L-Citrulline is the chosen preference over L-Arginine as L-Arginine has been shown to be less beneficial with long term therapy due to the intestinal and hepatic metabolism of L-Arginine to Ornithine and urea by arginase making oral delivery ineffective.

• However, L-Citrulline is not metabolised in the intestine or liver, L-Citrulline enters the kidneys, vascular endothelium and other tissues and is readily converted to L-Arginine, thus raising plasma and tissue levels of L-Arginine and enhancing NO production.


CVD: L-Citrulline preference over L-Arginine therapy, WHY?


61 year old male patient presenting with elevated blood pressure, shortness of breath and chest pain.


1500mg taken in water three times daily for a 6 week period.

Follow up Visit:

Patient showed a reduction in blood pressure, shortness of breath had improved & chest pain had ceased.


Enhancement of athletic sports performance


28 year old male patient presenting with decreased muscular endurance, post exercise muscle soreness, fatigue and wanting to enhance training capabilities.


3000 – 6000mg in water 1 hour before exercise.

Follow up Visit:

Patient reported significant improvement in exercise session, greater endurance, decreased fatigue and an increase in exercise duration, also reported being able to achieve a “really good muscle pump”. Post workout muscle soreness was also reported to have decreased.


Erectile Dysfunction


40 year old male patient presenting with erectile dysfunction associated symptoms. This is causing significant emotional distress and loss of self-confidence to patient..


1000mg taken in water three times daily for a 2 week period.

Follow up Visit:

Patient reported reduction in symptoms & improvement in emotional wellbeing as a result.


S QLD / N NSW Area Manager

Jessica Morland

Jess is a qualified Nutritionist with a Bachelor of Health Science in Nutritional Medicine. She believes that there is no one size fits all approach and is passionate about educating, inspiring and supporting clients and practitioners with a customised approach to healthcare. Specialties include preconception, pregnancy, post-natal and infant care. 

Jess is excited to build relationships, educate and share her knowledge with both retail and practitioners in South Queensland and Northern NSW.

Lauren Matich, BHSc (Nat.)

Lauren Matich

BHSc (Nat.)

Lauren is an NHAA accredited Clinical Naturopath with a Bachelor of Health Science. She is incredibly passionate about natural health and educating clients on the foundational importance of nutrition, lifestyle and stress management and believes complimenting these building blocks with nutraceutical support and functional testing often holds the key to optimal health and vitality. Lauren looks forward to supporting practitioners and clients in these key areas.

Specialties include supporting thyroid health, digestive disorders and mental health.