Methylation and sulfuration are complex processes and assessing them in clinical practice take skill, knowledge, and consideration of multiple genes and other factors. In this interview with Dr Fitzgerald, Dr David Quig discusses the assessment of methylation in clinical practice.
What you’ll learn in this podcast:
- The importance of considering multiple genes for a given metabolic process
- Understanding which patients are the best candidates for methylation investigation
- How to work with patients to explain that MTHFR status is just one data point in a much bigger, more complex picture
- The importance of looking at s-adenosylmethionine and sadenosylhomocysteine
- The dangers of compromised collection at labs and draw centers
- The methylation profile available from Doctor’s Data, which includes methionine, cysteine, Sadenosylmethionine, Sadenosylhomocysteine, homocysteine, and cystathionine
- Why Dr. Quig doesn’t recommend supplementing with SAM
- The dangers of supplementing with SAM long-term
- How people tolerate 5-methyltetrahydrofolate differently
- The one benefit—and the many limits—of synthetic folic acid
- Understanding overmethylation / overmethylators
- Interventions for high homocysteine
